Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK2 | O00142 | 6/20 | 0.34 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.33 |
| ▸ | TK1 | P04183 | 6/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223881 | 0.94 | TK2 (0.33) | TK2RNASE1TK1TYMP | |
| SCHEMBL4952762 | 0.92 | TK2 (0.39) | TK2RNASE1TK1TYMPHPGD | |
| SCHEMBL6421057 | 0.84 | RNASE1 (0.34) | TK2RNASE1TK1TYMPHPGD | |
| SCHEMBL4949400 | 0.83 | TK2 (0.36) | TK2RNASE1TK1TYMP | |
| SCHEMBL5668670 | 0.77 | RNASE1 (0.37) | TK2RNASE1TK1TYMPHPGD | |
| SCHEMBL3696551 | 0.76 | RNASE1 (0.36) | TK2RNASE1TK1TYMPHPGD | |
| SCHEMBL3516066 | 0.74 | TK2 (0.32) | TK2TK1HPGD | |
| SCHEMBL3300461 | 0.73 | TK2 (0.38) | TK2RNASE1TK1TYMP | |
| SCHEMBL313036 | 0.69 | TK1 (0.32) | TK2TK1HPGD | |
| SCHEMBL7195757 | 0.69 | TK1 (0.33) | TK2TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057284-A1 | COMPOSITIONS AND METHODS FOR THE MODULATION OF JNK PROTEINS | Isis Pharmaceuticals, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008017081-A1 | COMPOSITIONS AND METHODS FOR THE MODULATION OF JNK PROTEINS | ISIS PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| EP-1572713-A2 | ANTISENSE MODULATION OF ACYL-COA SYNTHETASE 1 EXPRESSION | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| EP-1442046-A4 | MAMMALIAN C-TYPE LECTINS | IMMUNEX CORP (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1442046-A2 | MAMMALIAN C-TYPE LECTINS | Immunex CorporatioN (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2004016749-A2 | ANTISENSE MODULATION OF ACYL-COA SYNTHETASE 1 EXPRESSION | PHARMACIA CORPORATION (US) | 2004-02-26 | — | — | WO | disclosed |
| WO-2003100017-A2 | OLIGONUCLEOTIDES HAVING MODIFIED NUCLEOSIDE UNITS | ISIS PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
| WO-2003099840-A1 | OLIGONUCLEOTIDES HAVING MODIFIED NUCLEOSIDE UNITS | ISIS PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
| US-20030211609-A1 | Antisense modulation of ara70 expression | COWSERT LEX M (US) | 2003-11-13 | — | — | US | disclosed |
| WO-2003031578-A2 | MAMMALIAN C-TYPE LECTINS | IMMUNEX CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |