Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 3/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 2/20 | 0.31 |
| ▸ | WDR5 | P61964 | 2/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695803 | 0.92 | FPR1 (0.38) | SLC16A3SLC16A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL3699026 | 0.87 | PTGDR2 (0.35) | ABCC9ABCC8KCNJ11KCNJ8CACNA1G | |
| SCHEMBL3700741 | 0.86 | PTGDR2 (0.34) | SLC16A3SLC16A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL3808568 | 0.86 | FPR1 (0.39) | SLC16A3SLC16A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL3699809 | 0.85 | FPR1 (0.39) | ABCC9ABCC8KCNJ11KCNJ8CACNA1G | |
| SCHEMBL4566346 | 0.83 | FPR1 (0.38) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL476413 | 0.82 | ABCC9 (0.35) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL3805205 | 0.81 | SLC16A3 (0.36) | SLC16A3SLC16A1CTSACYP3A4KMT2A | |
| SCHEMBL3814398 | 0.81 | RXRA (0.32) | SLC16A3SLC16A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL476324 | 0.81 | COMT (0.35) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |