Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.30 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.30 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.30 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.30 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.30 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696127 | 0.95 | P2RX7 (0.32) | PTGDR2P2RX7SLC16A3SLC16A1 | |
| SCHEMBL3700744 | 0.88 | PTGDR2 (0.33) | PTGDR2SLC16A3SLC16A1ABCC9ABCC8 | |
| SCHEMBL4137765 | 0.87 | NAMPT (0.33) | PTGDR2P2RX7SLC16A3SLC16A1ELANE | |
| SCHEMBL3697762 | 0.85 | KDM4E (0.33) | PTGDR2P2RX7SLC16A3SLC16A1ABCC9 | |
| SCHEMBL476395 | 0.84 | NAMPT (0.33) | — | |
| SCHEMBL3698416 | 0.83 | HTR2C (0.42) | PTGDR2PLCG1SLC16A3SLC16A1MEN1 | |
| SCHEMBL476326 | 0.82 | COMT (0.36) | PTGDR2KMT2A | |
| SCHEMBL3697999 | 0.82 | P2RX7 (0.33) | PTGDR2P2RX7SLC16A3SLC16A1ABCC9 | |
| SCHEMBL3697140 | 0.80 | SLC16A3 (0.34) | SLC16A3SLC16A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL476415 | 0.80 | HTR6 (0.35) | SLC16A3SLC16A1ABCC9ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |