Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CD38 | P28907 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704894 | 0.89 | ALDH1A1 (0.48) | MYCMAPTCD38AURKARPS6KB1 | |
| SCHEMBL3708751 | 0.86 | HTT (0.43) | MYCMAPTMAPK1SMN1; SMN2CD38 | |
| SCHEMBL3714023 | 0.85 | CD38 (0.50) | MYCMAPK1CD38AURKARPS6KB1 | |
| SCHEMBL7259314 | 0.84 | BCAT2 (0.57) | MAPTPKMMAPK1SMN1; SMN2BCAT2 | |
| SCHEMBL370726 | 0.78 | MYC (0.45) | MYCMAPTCD38BCAT2KEAP1 | |
| SCHEMBL1788703 | 0.77 | BCAT2 (0.59) | MYCMAPTBCAT2KEAP1NFE2L2 | |
| SCHEMBL4065283 | 0.77 | MYC (0.47) | MYCMAPTCD38AURKARPS6KB1 | |
| SCHEMBL28202663 | 0.76 | ALDH1A1 (0.42) | MAPTPKMMAPK1SMN1; SMN2CYP3A4 | |
| SCHEMBL5742619 | 0.76 | MYC (0.53) | MYCMAPTBCAT2KEAP1NFE2L2 | |
| SCHEMBL3135445 | 0.76 | MYC (0.53) | MYCMAPTBCAT2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197835-A1 | BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS | Prosidion Limited (GB) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009030962-A1 | BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS | PROSIDION LIMITED (GB) | 2009-03-12 | — | — | WO | disclosed |