Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ASPH | Q12797 | 3/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369158 | 0.72 | CYP2A6 (0.38) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL369547 | 0.71 | CYP2A6 (0.33) | MAPTMEN1KMT2AJAK2TYK2 | |
| SCHEMBL287634 | 0.70 | KDM4E (0.42) | DAOKDM4EASPHKDM8MAPT | |
| SCHEMBL3642157 | 0.70 | GPR35 (0.43) | DAOKDM4EALDH1A1L3MBTL1KMO | |
| SCHEMBL754061 | 0.68 | KMO (0.42) | KDM4EASPHKDM8ALDH1A1TSHR | |
| SCHEMBL20784800 | 0.68 | DAO (0.39) | DAOKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL755956 | 0.68 | KMO (0.42) | KDM4EASPHKDM8ALDH1A1TSHR | |
| SCHEMBL4726584 | 0.67 | IGFBP3 (0.47) | KDM4EASPHKDM8MAPTALDH1A1 | |
| SCHEMBL21261964 | 0.67 | DAO (0.46) | DAOKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL439545 | 0.65 | KDM4E (0.47) | DAOKDM4EASPHKDM8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |