Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369643 | 0.87 | RAB9A (0.45) | LMNASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL370420 | 0.82 | PTGFR (0.47) | LMNASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL1395269 | 0.80 | MAPT (0.39) | LMNAPTPN1PTPN2SMN1; SMN2MEN1 | |
| SCHEMBL13305519 | 0.79 | LMNA (0.56) | LMNAHSD17B10ESR1ESR2PTPN1 | |
| SCHEMBL1395396 | 0.75 | FAAH (0.45) | LMNASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL1395400 | 0.75 | FAAH (0.45) | LMNASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL1395399 | 0.74 | FFAR1 (0.35) | LMNAPTPN1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL368441 | 0.72 | PTPN1 (0.50) | PTPN1PTPN2MEN1KMT2ARAB9A | |
| SCHEMBL11772434 | 0.71 | MME (0.51) | LMNAHSD17B10MEN1KMT2ARAB9A | |
| SCHEMBL21579845 | 0.70 | ESR1 (0.58) | LMNAHSD17B10ESR1ESR2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |