Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CCKAR | P32238 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369940 | 0.87 | LMNA (0.46) | RAB9ALMNAKMT2AMEN1MAPT | |
| SCHEMBL13305527 | 0.82 | ALDH1A1 (0.53) | RAB9ALMNAKMT2ANPSR1MEN1 | |
| SCHEMBL370420 | 0.79 | PTGFR (0.47) | LMNAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2922282 | 0.78 | MITF (0.59) | RAB9ALMNAKMT2AMEN1MAPT | |
| SCHEMBL1395269 | 0.78 | MAPT (0.39) | RAB9ALMNAKMT2AMEN1MAPT | |
| SCHEMBL1395400 | 0.77 | FAAH (0.45) | LMNAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1395396 | 0.77 | FAAH (0.45) | LMNAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11775180 | 0.74 | POLB (0.56) | RAB9ALMNAKMT2ANPSR1MEN1 | |
| SCHEMBL28067587 | 0.73 | ALDH1A1 (0.57) | RAB9ALMNAKMT2ANPSR1MEN1 | |
| SCHEMBL21579875 | 0.73 | CA1 (0.58) | RAB9ALMNAKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |