Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221418 | 0.81 | ACHE (0.49) | ACHEMMP2PSEN1PSEN2APH1B | |
| SCHEMBL2220964 | 0.81 | PSEN1 (0.70) | ACHEMMP2PSEN1PSEN2APH1B | |
| SCHEMBL2221744 | 0.79 | ACHE (0.50) | ACHEMMP2PSEN1PSEN2APH1B | |
| SCHEMBL2220869 | 0.79 | TRPA1 (0.53) | ACHEMMP2PSEN1PSEN2APH1B | |
| SCHEMBL2221432 | 0.79 | PSEN1 (0.72) | ACHEMMP2PSEN1PSEN2APH1B | |
| SCHEMBL2219745 | 0.75 | ACHE (0.54) | ACHEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30004987 | 0.75 | MEN1 (0.60) | MEN1KMT2ALMNAPKMALDH1A1 | |
| SCHEMBL13812162 | 0.75 | ACHE (0.68) | ACHEMMP2MEN1KMT2AHSD11B1 | |
| SCHEMBL29551906 | 0.74 | MEN1 (0.67) | MEN1KMT2ALMNAPKMALDH1A1 | |
| SCHEMBL25317014 | 0.74 | ALDH1A1 (0.43) | ACHEPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836200-B1 | BENZISOTHIAZOLE-1, 1-DIOXIDE ACTING AS ANTAGONISTS TO THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF | ABBOTT LAB (US) | 2012-05-16 | — | — | EP | disclosed |
| US-7615570-B2 | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof | ABBOTT LABORATORIES (US) | 2009-11-10 | — | — | US | disclosed |
| US-20060148867-A1 | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof | ABBVIE INC. | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148867-A1 | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof | AVPR1A, AVPR1B, AVPR2 | ACHE 1332/4885MMP2 2238/4885PSEN1 3358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.