Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | IAPP | P10997 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | GRB2 | P62993 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701186 | 0.89 | ELANE (0.41) | KMT2AGLAMEN1CYP3A4HSD17B3 | |
| SCHEMBL12285606 | 0.88 | ELANE (0.43) | KMT2AGLAMEN1CYP3A4HSD17B3 | |
| SCHEMBL30302271 | 0.79 | CYP3A4 (0.48) | KMT2AGLAMEN1CYP3A4HSD17B3 | |
| SCHEMBL2314356 | 0.79 | MEN1 (0.42) | KMT2AGLAMEN1CYP3A4ALDH1A1 | |
| SCHEMBL3700781 | 0.77 | MEN1 (0.50) | KMT2AGLAMEN1CYP3A4HSD17B3 | |
| SCHEMBL6912133 | 0.76 | CYP3A4 (0.54) | KMT2AGLAMEN1CYP3A4HSD17B3 | |
| SCHEMBL23922349 | 0.75 | ALDH1A1 (0.39) | KMT2AGLAMEN1CYP3A4HSD17B3 | |
| SCHEMBL6916622 | 0.74 | ALDH1A1 (0.53) | KMT2AGLAMEN1CYP3A4HSD17B3 | |
| SCHEMBL563659 | 0.72 | ALOX15 (0.54) | KMT2AGLAMEN1CYP3A4ALDH1A1 | |
| Benzene SCHEMBL27508653 | 0.72 | CYP3A4 (0.48) | KMT2AGLAMEN1CYP3A4HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200325508-A1 | GENES AND PROTEINS FOR AROMATIC POLYKETIDE SYNTHESIS | UNIVERSITY OF SASKATCHEWAN (CA) | 2020-10-15 | — | — | US | disclosed |
| US-10718000-B2 | Genes and proteins for aromatic polyketide synthesis | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2020-07-21 | — | — | US | disclosed |
| US-20190169661-A1 | GENES AND PROTEINS FOR AROMATIC POLYKETIDE SYNTHESIS | UNIVERSITY OF SASKATCHEWAN (CA) | 2019-06-06 | — | — | US | disclosed |
| US-20170233779-A1 | GENES AND PROTEINS FOR AROMATIC POLYKETIDE SYNTHESIS | UNIVERSITY OF SASKATCHEWAN (CA) | 2017-08-17 | — | — | US | disclosed |
| US-20170233779-A1 | GENES AND PROTEINS FOR AROMATIC POLYKETIDE SYNTHESIS | UNIVERSITY OF SASKATCHEWAN (CA) | 2017-08-17 | — | — | US | disclosed |
| US-9611460-B2 | Genes and proteins for aromatic polyketide synthesis | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2017-04-04 | — | — | US | disclosed |
| US-9611460-B2 | Genes and proteins for aromatic polyketide synthesis | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2017-04-04 | — | — | US | disclosed |
| US-20130067619-A1 | GENES AND PROTEINS FOR AROMATIC POLYKETIDE SYNTHESIS | UNIVERSITY OF SASKATCHEWAN (CA) | 2013-03-14 | — | — | US | disclosed |
| US-20130067619-A1 | GENES AND PROTEINS FOR AROMATIC POLYKETIDE SYNTHESIS | UNIVERSITY OF SASKATCHEWAN (CA) | 2013-03-14 | — | — | US | disclosed |
| US-20120122180-A1 | INCORPORATION OF TYPE III POLYKETIDE SYNTHASES INTO MULTIDOMAIN PROTEINS OF THE TYPE I AND III POLYKETIDE SYNTHASE AND FATTY ACID SYNTHASE FAMILIES | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2012-05-17 | — | — | US | disclosed |
| US-20080233628-A1 | Incorporation of type III polyketide synthases into multidomain proteins of the type I and III polyketide synthase and fatty acid synthase families | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2008-09-25 | — | — | US | disclosed |