Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | SCN1A | P35498 | 2/20 | 0.61 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919628 | 0.92 | NSD2 (0.83) | NSD2SMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL6848713 | 0.88 | NSD2 (0.58) | NSD2SMN1; SMN2ALDH1A1SCN1ASCN2A | |
| SCHEMBL10453019 | 0.88 | NSD2 (0.58) | NSD2SMN1; SMN2ALDH1A1SCN1ASCN2A | |
| SCHEMBL20026077 | 0.84 | NSD2 (0.70) | NSD2ALDH1A1SCN1ASCN2ASCN3A | |
| SCHEMBL4470111 | 0.84 | NSD2 (0.71) | NSD2SMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4441217 | 0.84 | NSD2 (1.00) | NSD2SMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL11107108 | 0.83 | HDAC1 (0.53) | NSD2SMN1; SMN2ALDH1A1SCN1ASCN2A | |
| SCHEMBL11107112 | 0.83 | HDAC1 (0.53) | NSD2SMN1; SMN2ALDH1A1SCN1ASCN2A | |
| SCHEMBL11372267 | 0.83 | TBXA2R (0.69) | NSD2SMN1; SMN2ALDH1A1SCN1ASCN2A | |
| SCHEMBL9718394 | 0.83 | NSD2 (0.52) | NSD2SMN1; SMN2ALDH1A1SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809584-B2 | N-substituted-N-phenylethylsulfonamides for the identification of biological and pharmacological activity | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S.A. (ES) | 2014-08-19 | — | — | US | disclosed |
| US-8809584-B2 | N-substituted-N-phenylethylsulfonamides for the identification of biological and pharmacological activity | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S.A. (ES) | 2014-08-19 | — | — | US | disclosed |
| US-8809584-B2 | N-substituted-N-phenylethylsulfonamides for the identification of biological and pharmacological activity | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S.A. (ES) | 2014-08-19 | — | — | US | disclosed |
| US-20120149909-A1 | N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | AMIRA THERAPEUTICS, S.L. (ES) | 2012-06-14 | — | — | US | disclosed |
| US-20120149909-A1 | N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | AMIRA THERAPEUTICS, S.L. (ES) | 2012-06-14 | — | — | US | disclosed |
| US-20120149909-A1 | N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | AMIRA THERAPEUTICS, S.L. (ES) | 2012-06-14 | — | — | US | disclosed |
| US-20120122920-A1 | LIBRARIES OF N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR DRUG DISCOVERY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122710-A1 | LIBRARIES OF N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122710-A1 | LIBRARIES OF N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122920-A1 | LIBRARIES OF N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR DRUG DISCOVERY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122920-A1 | LIBRARIES OF N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR DRUG DISCOVERY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122710-A1 | LIBRARIES OF N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122920-A1 | LIBRARIES OF N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR DRUG DISCOVERY | TST, PNMT, PTPRS | NSD2 1902/4885SMN1; SMN2 2551/4885ALDH1A1 1565/4885 |
| US-20120149909-A1 | N-SUBSTITUTED-N-PHENYLETHYLSULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | NAT1, TST, PNMT | NSD2 2838/4885SMN1; SMN2 2852/4885ALDH1A1 2578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.