Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP9 | P55211 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 5/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157170 | 0.92 | CAPN1 (0.47) | CASP3CASP7CASP1CASP9MMP3 | |
| SCHEMBL31248471 | 0.90 | CAPN1 (0.51) | CASP3CASP7CASP1CASP9MMP3 | |
| SCHEMBL19190188 | 0.88 | MMP3 (0.49) | CASP3CASP7CASP1CASP9MMP3 | |
| SCHEMBL2034855 | 0.87 | CAPN1 (0.48) | CASP3CASP7CASP1CASP9MMP3 | |
| SCHEMBL3491057 | 0.83 | PTPN1 (0.47) | CASP3CASP7CASP1CASP9PSMB1 | |
| SCHEMBL9961858 | 0.82 | CASP3 (0.65) | CASP3CASP7CASP1CASP9CTSL | |
| SCHEMBL7938093 | 0.80 | CAPN1 (0.60) | CTSLCTSKCAPN1CTSB | |
| SCHEMBL20257154 | 0.80 | REN (0.46) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL23133281 | 0.80 | REN (0.48) | CTSLCTSKCAPN1CTSB | |
| SCHEMBL20257155 | 0.80 | REN (0.48) | CTSLCTSKCAPN1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838645-B2 | comprising antibodies that specifically bind caspase-8 as inhibitors; cancer; activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy | UNIVERSITY OF MARYLAND COLLEGE PARK (US) | 2010-11-23 | — | — | US | disclosed |
| US-20050276809-A1 | comprising antibodies that specifically bind caspase-8 as inhibitors; cancer; activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-12-15 | — | — | US | disclosed |