Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4236137 | 0.94 | RCE1 (0.45) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL9278231 | 0.92 | TSHR (0.41) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL14094034 | 0.91 | TSHR (0.44) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL1571975 | 0.91 | TSHR (0.52) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL15518976 | 0.88 | SLC1A3 (0.42) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL17697790 | 0.88 | RCE1 (0.44) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL10967316 | 0.88 | TSHR (0.41) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7739982 | 0.86 | RCE1 (0.38) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL683166 | 0.84 | RCE1 (0.47) | TSHRIDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL23855801 | 0.83 | IDO1 (0.52) | TSHRIDO1SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250154181-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2025-05-15 | — | — | US | disclosed |
| US-12173021-B2 | Treprostinil prodrugs | UNITED THERAPEUTICS CORPORATION (US) | 2024-12-24 | — | — | US | disclosed |
| US-20240051979-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2024-02-15 | — | — | US | disclosed |
| US-11634443-B2 | Treprostinil prodrugs | UNITED THERAPEUTICS CORPORATION (US) | 2023-04-25 | — | — | US | disclosed |
| EP-4017588-A1 | TREPROSTINIL PRODRUGS | United Therapeutics Corporation (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114616225-A | Treprostinil prodrugs | 联合治疗公司 | 2022-06-10 | — | — | CN | disclosed |
| WO-2021041320-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2021-03-04 | — | — | WO | disclosed |
| US-20210054009-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2021-02-25 | — | — | US | disclosed |
| US-9017726-B2 | Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-04-28 | — | — | US | disclosed |
| US-20140031289-A1 | POLY(ORGANOPHOSPHAZENE) CONTAINING DEGRADATION CONTROLLABLE IONIC GROUP, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-01-30 | — | — | US | disclosed |
| US-20120121517-A1 | BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE)-SUPERPARAMAGNETIC NANOPARTICLE COMPLEX, PREPARATION METHOD AND USE THEREOF | Korean Institute of Science and Technology of Seoul, Republic of Korea | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250154181-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | TSHR 1445/4885IDO1 2968/4885SLC1A3 637/4885 |
| US-20120121517-A1 | BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE)-SUPERPARAMAGNETIC NANOPARTICLE COMPLEX, PREPARATION METHOD AND USE THEREOF | PHOSPHO1, HSPA2, FEM1B | TSHR 929/4885IDO1 2168/4885SLC1A3 3872/4885 |
| US-20210054009-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | TSHR 1445/4885IDO1 2968/4885SLC1A3 637/4885 |
| US-20140031289-A1 | POLY(ORGANOPHOSPHAZENE) CONTAINING DEGRADATION CONTROLLABLE IONIC GROUP, PREPARATION METHOD THEREOF AND USE THEREOF | PHOSPHO1, PLCB3, INPP5D | TSHR 3450/4885IDO1 2965/4885SLC1A3 3062/4885 |
| US-20240051979-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | TSHR 1445/4885IDO1 2968/4885SLC1A3 637/4885 |
| US-12173021-B2 | Treprostinil prodrugs | TYMP, TK1, DCTPP1 | TSHR 1445/4885IDO1 2968/4885SLC1A3 637/4885 |
| US-11634443-B2 | Treprostinil prodrugs | TYMP, TK1, DCTPP1 | TSHR 1445/4885IDO1 2968/4885SLC1A3 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.