Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 5/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4126577 | 0.85 | MDM2 (0.34) | MDM2RXRAGRIN1GRIN2BRIPK1 | |
| SCHEMBL4123622 | 0.84 | MDM2 (0.36) | MDM2RXRAGRIN1GRIN2BRIPK1 | |
| SCHEMBL4123630 | 0.84 | MDM2 (0.38) | MDM2RIPK1NOTUM | |
| SCHEMBL3701558 | 0.81 | RIPK1 (0.32) | MDM2RIPK1NOTUM | |
| SCHEMBL3814318 | 0.80 | MDM2 (0.33) | MDM2RXRAGRIN1GRIN2BRIPK1 | |
| SCHEMBL3814316 | 0.80 | MDM2 (0.33) | MDM2RXRAGRIN1GRIN2BRIPK1 | |
| SCHEMBL3696768 | 0.80 | HTR2C (0.45) | MDM2RXRAGRIN1GRIN2BRIPK1 | |
| SCHEMBL3814311 | 0.80 | RIPK1 (0.36) | MDM2RXRAGRIN1GRIN2BRIPK1 | |
| SCHEMBL3699131 | 0.79 | PDE4B (0.39) | RIPK1NOTUM | |
| SCHEMBL4135601 | 0.76 | SMN1; SMN2 (0.34) | MDM2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-B1 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2014-12-31 | — | — | EP | disclosed |
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| US-20090156642-A1 | 5-Membered heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156642-A1 | 5-Membered heterocyclic compound | CEL, PGA5, COG5 | MDM2 4783/4885RXRA 2919/4885GRIN1 3185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.