Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | AKT2 | P31751 | 3/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | GABBR2 | O75899 | 6/20 | 0.53 |
| ▸ | GABBR1 | Q9UBS5 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3525702 | 0.97 | CHRNA7 (0.66) | CHRNA7HTR2ATAAR1AKT2CHRNB2 | |
| SCHEMBL21068075 | 0.93 | HTR2A (0.73) | CHRNA7HTR2ATAAR1AKT2CHRNB2 | |
| SCHEMBL1979244 | 0.93 | HTR2A (0.73) | CHRNA7HTR2ATAAR1AKT2CHRNB2 | |
| Hydrochloric Acid SCHEMBL1977273 | 0.91 | CHRNA7 (0.70) | CHRNA7HTR2ATAAR1AKT2CHRNB2 | |
| SCHEMBL4619055 | 0.80 | HRH1 (0.62) | CHRNA7HTR2ATAAR1AKT2GABBR2 | |
| SCHEMBL10507284 | 0.79 | GABBR2 (0.64) | CHRNA7GABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL3317983 | 0.77 | TSHR (0.48) | CHRNA7TAAR1AKT2GABBR2GABBR1 | |
| Hydrochloric Acid SCHEMBL10681987 | 0.77 | GABBR2 (0.62) | CHRNA7GABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL3702383 | 0.77 | TSHR (0.48) | CHRNA7TAAR1AKT2GABBR2GABBR1 | |
| SCHEMBL1953110 | 0.77 | ADRB2 (0.52) | CHRNA7AKT2GABBR2GABBR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160250187-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2016-09-01 | — | — | US | disclosed |
| US-9283226-B2 | Pyrazole derivatives as protein kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2016-03-15 | — | — | US | disclosed |
| US-20140271662-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2014-09-18 | — | — | US | disclosed |
| US-8541461-B2 | Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2013-09-24 | — | — | US | disclosed |
| US-20130005702-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2013-01-03 | — | — | US | disclosed |
| US-8343953-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2013-01-01 | — | — | US | disclosed |
| US-8247576-B2 | Pyrazole derivatives as protein kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2012-08-21 | — | — | US | disclosed |
| US-20110144080-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2011-06-16 | — | — | US | disclosed |
| US-7855292-B2 | Cholecystokinin (CCK) receptor ligands; antagonists; 3-(5-Bromo-thiophen-2-yl)-2-[4-chloro-2-(quinoxaline-5-sulfonylamino)-benzoylamino]-propionic acid methy; pain, drug dependence, anxiety, panic attack, schizophrenia, pancreatic disorders, secretory disorders, ulcers, cancers; improved pharmacokinetics | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-21 | — | — | US | disclosed |
| US-20100292240-A1 | SULFONAMIDE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-18 | — | — | US | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |
| US-6150335-A | TREATMENT FOR PAIN | ASTRA AB (SE) | 2000-11-21 | — | — | US | disclosed |
| EP-0946588-A1 | USE OF DIPEPTIDE DERIVATIVES | Astra Aktiebolag (publ) (SE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028327-A1 | NEW USE OF DIPEPTIDE DERIVATIVES | ASTRA AKTIEBOLAG (PUBL) (SE) | 1998-07-02 | — | — | WO | disclosed |
| EP-0139358-B1 | N6-SUBSTITUTED DIARYLALKYL ADENOSINES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | WARNER-LAMBERT COMPANY (US) | 1988-11-09 | — | — | EP | disclosed |
| EP-0251339-A2 | N6- substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1988-01-07 | — | — | EP | disclosed |
| US-4657898-A | CARDIOVACULAR AND PSYCHOLOGICAL DISORDERS, ANALGESICS, OR SEDATIVES | WARNER-LAMBERT COMPANY (US) | 1987-04-14 | — | — | US | disclosed |
| US-4657897-A | N6 -substituted adenosines for treating pain | WARNER-LAMBERT COMPANY (US) | 1987-04-14 | — | — | US | disclosed |
| US-4649204-A | ANTIDEPRESSANTS | MCNEILAB, INC. (US) | 1987-03-10 | — | — | US | disclosed |
| EP-0139358-A2 | N6-substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1985-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144080-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | GRK3, GRK2, NR0B2 | CHRNA7 1844/4885HTR2A 907/4885TAAR1 1660/4885 |
| US-20130005702-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | PRKCB, MAP3K19, MAP4K2 | CHRNA7 4099/4885HTR2A 3715/4885TAAR1 4623/4885 |
| US-20140271662-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | GRK3, GRK2, NR0B2 | CHRNA7 1717/4885HTR2A 862/4885TAAR1 1702/4885 |
| US-20100292240-A1 | SULFONAMIDE COMPOUNDS | CCKAR, CCKBR, TAS1R2 | CHRNA7 4748/4885HTR2A 860/4885TAAR1 2804/4885 |
| US-20160250187-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | GRK3, GRK2, NR0B2 | CHRNA7 1717/4885HTR2A 862/4885TAAR1 1702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.