Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.45 |
| ▸ | THRA | P10827 | 5/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | DHPS | P49366 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12312864 | 0.84 | THRB (0.52) | THRBTHRARORCL3MBTL1KDM4E | |
| SCHEMBL12312860 | 0.82 | THRB (0.50) | THRBTHRARORCL3MBTL1KDM4E | |
| SCHEMBL12312737 | 0.79 | THRB (0.61) | THRBTHRARORC | |
| SCHEMBL22959367 | 0.79 | THRB (0.49) | THRBTHRARORCL3MBTL1ALDH1A1 | |
| SCHEMBL18932876 | 0.78 | THRB (0.45) | THRBRORCKDM4EDHPSALDH1A1 | |
| SCHEMBL5326111 | 0.78 | THRB (0.39) | THRBTHRARORCHDAC4HDAC2 | |
| SCHEMBL29572032 | 0.76 | KDM4E (0.64) | L3MBTL1KDM4EMAPK1RECQLHDAC4 | |
| SCHEMBL835688 | 0.76 | KDM4E (0.64) | L3MBTL1KDM4EMAPK1RECQLHDAC4 | |
| SCHEMBL5326116 | 0.75 | THRB (0.39) | THRBTHRARORCL3MBTL1KDM4E | |
| SCHEMBL5324856 | 0.75 | ALDH1A1 (0.45) | THRBTHRARORCALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |