Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.58 |
| ▸ | THRA | P10827 | 10/20 | 0.58 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701595 | 0.89 | THRA (0.62) | THRBTHRA | |
| SCHEMBL3706464 | 0.87 | THRA (0.61) | THRBTHRA | |
| SCHEMBL3708498 | 0.85 | THRA (0.61) | THRBTHRA | |
| SCHEMBL3710195 | 0.85 | THRB (0.60) | THRBTHRA | |
| SCHEMBL3707164 | 0.84 | THRB (0.64) | THRBTHRARORC | |
| SCHEMBL3713885 | 0.82 | THRA (0.57) | THRBTHRA | |
| SCHEMBL3704572 | 0.82 | THRB (0.54) | THRBTHRA | |
| SCHEMBL3223233 | 0.82 | THRA (0.69) | THRBTHRA | |
| SCHEMBL3221807 | 0.82 | THRA (0.61) | THRBTHRA | |
| SCHEMBL3707185 | 0.81 | THRA (0.52) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |