Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.50 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.50 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | ASIC3 | Q9UHC3 | 5/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | CD44 | P16070 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384718 | 0.95 | PARP1 (0.50) | CD274PARP1PARP2PARP3BCAT2 | |
| SCHEMBL3704728 | 0.88 | CD274 (0.55) | CD274ASIC3SYKPNMTCD44 | |
| SCHEMBL16417122 | 0.84 | ASIC3 (0.47) | CD274PARP1PARP2PARP3ASIC3 | |
| SCHEMBL30300429 | 0.81 | BCAT2 (0.54) | BCAT2CHEK1 | |
| SCHEMBL4553211 | 0.79 | CD274 (0.60) | CD274ASIC3SYKPNMTCD44 | |
| SCHEMBL3707604 | 0.77 | ASIC3 (0.55) | PARP1PARP2PARP3ASIC3PNMT | |
| SCHEMBL6245850 | 0.77 | PARP1 (0.44) | CD274PARP1PARP2PARP3ASIC3 | |
| SCHEMBL1785176 | 0.77 | ASIC3 (0.56) | CD274PARP1PARP2PARP3ASIC3 | |
| SCHEMBL20538841 | 0.75 | CD274 (0.48) | CD274PARP1PARP2PARP3ASIC3 | |
| SCHEMBL19281456 | 0.75 | ASIC3 (0.51) | PARP1PARP2PARP3ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200989-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009036144-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-19 | — | — | WO | claimed |
| US-6110934-A | Substituted benzamide derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-08-29 | — | — | US | disclosed |
| CN-1222145-A | Substituted benzamide derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM PLC (GB) | 1999-07-07 | — | — | CN | disclosed |
| EP-0906283-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997048683-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | disclosed |