Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.55 |
| ▸ | ASIC3 | Q9UHC3 | 5/20 | 0.48 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 2/20 | 0.45 |
| ▸ | CD44 | P16070 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3703063 | 0.88 | CD274 (0.54) | CD274ASIC3SYKPNMTCD44 | |
| SCHEMBL20538841 | 0.84 | CD274 (0.48) | CD274ASIC3PRCPSYKUSP28 | |
| SCHEMBL6384718 | 0.82 | PARP1 (0.50) | CD274SYKPNMTCD44MAOB | |
| SCHEMBL4553211 | 0.80 | CD274 (0.60) | CD274ASIC3PRCPSYKPNMT | |
| SCHEMBL14863482 | 0.79 | SYK (0.49) | CD274ASIC3SYK | |
| SCHEMBL23785442 | 0.79 | PARP10 (0.44) | MEN1KMT2AATM | |
| SCHEMBL20538826 | 0.79 | CD274 (0.45) | CD274PRCPSYKPNMT | |
| Hydrochloric Acid SCHEMBL861787 | 0.78 | FABP4 (0.44) | CD274 | |
| SCHEMBL2804700 | 0.77 | MEN1 (0.58) | MEN1KMT2AATMUSP28 | |
| SCHEMBL6347388 | 0.77 | ASIC3 (0.65) | CD274ASIC3PRCPPNMTCD44 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200989-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2010-06-30 | — | — | EP | disclosed |
| EP-2200998-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009036117-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009036144-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-19 | — | — | WO | disclosed |