Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.48 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | METAP1 | P53582 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885522 | 0.90 | CYP24A1 (0.48) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 | |
| SCHEMBL3654990 | 0.90 | CYP24A1 (0.48) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 | |
| SCHEMBL9995721 | 0.85 | CYP24A1 (0.47) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 | |
| SCHEMBL5077391 | 0.85 | CYP19A1 (0.57) | CYP24A1CYP27A1CYP26A1CYP19A1DRD2 | |
| SCHEMBL16567983 | 0.85 | MAOA (0.48) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 | |
| SCHEMBL15012851 | 0.83 | PTGS2 (0.44) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 | |
| SCHEMBL6669546 | 0.82 | CYP24A1 (0.53) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 | |
| SCHEMBL15012600 | 0.81 | GID4 (0.61) | CYP24A1CYP27A1CYP26A1CYP19A1DRD2 | |
| SCHEMBL9995684 | 0.81 | SLC6A2 (0.49) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 | |
| SCHEMBL9995652 | 0.81 | CYP24A1 (0.47) | CYP24A1CYP27A1CYP26A1CYP19A1METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200962-A1 | BENZOCYCLOHEPTENE DERIVATIVES AS ESTROGENS HAVING SELECTIVE ACTIVITY | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009047343-A1 | BENZOCYCLOHEPTENE DERIVATIVES AS ESTROGENS HAVING SELECTIVE ACTIVITY | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-04-16 | — | — | WO | claimed |