Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 17/20 | 0.77 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.69 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.69 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707375 | 0.90 | RAB9A (0.81) | NAMPTTAS1R3TAS1R1TAS1R2NPC1 | |
| SCHEMBL10226370 | 0.88 | NPC1 (0.78) | NAMPTTAS1R3TAS1R1TAS1R2NPC1 | |
| SCHEMBL3704115 | 0.88 | NAMPT (0.78) | NAMPT | |
| SCHEMBL3709164 | 0.87 | NAMPT (1.00) | NAMPTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3698520 | 0.86 | NAMPT (0.75) | NAMPTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3703827 | 0.85 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3697328 | 0.83 | NAMPT (1.00) | NAMPTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3701200 | 0.83 | NAMPT (0.71) | NAMPTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL24947713 | 0.83 | NAMPT (0.67) | NAMPTNPC1RAB9A | |
| SCHEMBL3698598 | 0.83 | NAMPT (0.73) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093624-B2 | NAMPT and ROCK inhibitors | ABBVIE INC. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-2776393-B1 | NAMPT INHIBITORS | ABBVIE INC (US) | 2017-12-20 | — | — | EP | disclosed |
| US-20170253562-A1 | Nampt Inhibitors | ABBVIE INC (US) | 2017-09-07 | — | — | US | disclosed |
| CN-104039762-B | Nampt inhibitor | ABBVIE INC. (US) | 2016-11-30 | — | — | CN | disclosed |
| US-9302989-B2 | NAMPT and rock inhibitors | ABBVIE INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20160031813-A1 | Nampt Inhibitors | ABBVIE INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031880-A1 | Nampt and Rock Inhibitors | ABBVIE INC. (US) | 2016-02-04 | — | — | US | disclosed |
| EP-2776393-A1 | NAMPT INHIBITORS | Abbvie Inc. (US) | 2014-09-17 | — | — | EP | disclosed |
| EP-2640698-A1 | NAMPT AND ROCK INHIBITORS | AbbVie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2013067710-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2013-05-16 | — | — | WO | disclosed |
| WO-2012067965-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10093624-B2 | NAMPT and ROCK inhibitors | NAMPT, NNMT, NADK | NAMPT 1/4885TAS1R3 3988/4885TAS1R1 4181/4885 |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | NAMPT, NNMT, NME2 | NAMPT 1/4885TAS1R3 4597/4885TAS1R1 4638/4885 |
| US-20170253562-A1 | Nampt Inhibitors | NAMPT, NNMT, NAPRT | NAMPT 1/4885TAS1R3 4117/4885TAS1R1 4081/4885 |
| US-20160031813-A1 | Nampt Inhibitors | NAMPT, NNMT, NAPRT | NAMPT 1/4885TAS1R3 4117/4885TAS1R1 4081/4885 |
| US-20160031880-A1 | Nampt and Rock Inhibitors | NAMPT, NNMT, NME2 | NAMPT 1/4885TAS1R3 4597/4885TAS1R1 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.