Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.47 |
| ▸ | THRB | P10828 | 8/20 | 0.47 |
| ▸ | THRA | P10827 | 3/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706695 | 0.89 | THRB (0.42) | RORCTHRBTHRAC5AR1 | |
| SCHEMBL3711993 | 0.87 | THRB (0.45) | RORCTHRBTHRA | |
| SCHEMBL3812710 | 0.86 | THRB (0.46) | RORCTHRBTHRAC5AR1 | |
| SCHEMBL3705917 | 0.82 | THRB (0.49) | RORCTHRBTHRA | |
| SCHEMBL3812706 | 0.82 | THRB (0.45) | RORCTHRBTHRA | |
| SCHEMBL3703969 | 0.81 | THRA (0.53) | THRBTHRA | |
| SCHEMBL3221348 | 0.81 | THRB (0.48) | RORCTHRBTHRA | |
| SCHEMBL3713161 | 0.80 | THRB (0.43) | RORCTHRBTHRA | |
| SCHEMBL3706521 | 0.80 | RORC (0.53) | RORCTHRBTHRA | |
| SCHEMBL3227188 | 0.78 | THRB (0.46) | RORCTHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |