Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.43 |
| ▸ | RORC | P51449 | 8/20 | 0.43 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711993 | 0.93 | THRB (0.45) | THRBRORCTHRALMNA | |
| SCHEMBL3709382 | 0.93 | RORC (0.51) | THRBRORCTHRA | |
| SCHEMBL3227188 | 0.89 | THRB (0.46) | THRBRORCTHRA | |
| SCHEMBL3706058 | 0.88 | RORC (0.51) | THRBRORCTHRA | |
| SCHEMBL3706521 | 0.86 | RORC (0.53) | THRBRORCTHRA | |
| SCHEMBL3221348 | 0.86 | THRB (0.48) | THRBRORCTHRA | |
| SCHEMBL3226111 | 0.85 | THRB (0.43) | THRBRORCTHRA | |
| SCHEMBL3707589 | 0.84 | THRB (0.38) | THRBRORCTHRALMNA | |
| SCHEMBL3702743 | 0.84 | RORC (0.47) | THRBRORCTHRA | |
| SCHEMBL3706479 | 0.84 | RORC (0.51) | THRBRORCTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |