Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252895 | 0.85 | CCNE2 (0.35) | ADORA2ACCNE2CCNE1CDK2MAP2K1 | |
| SCHEMBL5252606 | 0.80 | PDE2A (0.34) | CCNE2CCNE1CDK2MAP2K1KDM4E | |
| SCHEMBL3702960 | 0.77 | GRIA1 (0.38) | ADORA2ACDK2GRIA1NPC1KLK7 | |
| SCHEMBL5593135 | 0.76 | EGLN2 (0.40) | CCNE1CDK2MAP2K1NPC1 | |
| SCHEMBL14270922 | 0.74 | EGLN2 (0.44) | KDM4EGABRG2GABRB3GABRA3NPC1 | |
| SCHEMBL3707772 | 0.74 | KDM4E (0.43) | ADORA2ACCNE2CCNE1CDK2MAP2K1 | |
| SCHEMBL5252323 | 0.69 | PDE2A (0.38) | KDM4EGAAMAPK1 | |
| SCHEMBL15685795 | 0.69 | MAP2K1 (0.38) | MAP2K1KDM4EGAAMAPTMAPK1 | |
| SCHEMBL9870867 | 0.69 | GABRA1 (0.42) | ADORA2ACCNE2CCNE1CDK2MAP2K1 | |
| SCHEMBL2978903 | 0.68 | MAPT (0.42) | ADORA2AMAP2K1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |