Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870091 | 0.79 | KDM4E (0.55) | GABRA1GABRG2GABRB3GABRA3MAP2K1 | |
| SCHEMBL9869845 | 0.79 | EGLN2 (0.50) | GABRA1GABRG2GABRB3GABRA3CCNE2 | |
| SCHEMBL11009148 | 0.73 | BACE1 (0.49) | GABRA1GABRG2GABRB3GABRA3PDE2A | |
| SCHEMBL11009952 | 0.72 | CYP2A6 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7224559 | 0.71 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL9870239 | 0.70 | KDM4E (0.43) | PDE2ACDK2CDK9MAPTKDM4E | |
| SCHEMBL259043 | 0.69 | KDM4E (0.50) | PDE2AMAPTKDM4E | |
| SCHEMBL3704252 | 0.69 | ADORA2A (0.41) | GABRA1GABRG2GABRB3GABRA3CCNE2 | |
| SCHEMBL9869878 | 0.69 | KDM4E (0.44) | PDE2AMAPTKDM4EMAPK1 | |
| SCHEMBL3707772 | 0.69 | KDM4E (0.43) | GABRA1GABRG2GABRB3GABRA3CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | disclosed |