Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.44 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP12 | P39900 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.32 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706580 | 0.93 | MMP2 (0.36) | MMP2MMP9MMP12CYP2C9HPGD | |
| SCHEMBL3702315 | 0.89 | LPAR1 (0.40) | TP53MAPTKDM4ESLC26A6USP2 | |
| SCHEMBL3706560 | 0.87 | KDM4E (0.36) | TP53MAPTKDM4EUSP2POLB | |
| SCHEMBL2335539 | 0.84 | LPAR1 (0.45) | TP53MAPTKDM4ESLC26A6USP2 | |
| SCHEMBL3703222 | 0.84 | LPAR1 (0.35) | TP53MAPTKDM4EUSP2POLB | |
| SCHEMBL3703091 | 0.84 | KDM4E (0.36) | TP53MAPTKDM4ESLC26A6USP2 | |
| SCHEMBL3712524 | 0.83 | LPAR1 (0.42) | TP53MAPTKDM4ESLC26A6USP2 | |
| SCHEMBL3701871 | 0.82 | KDM4E (0.34) | TP53MAPTKDM4EUSP2POLB | |
| SCHEMBL3709661 | 0.81 | LPAR1 (0.41) | HPGDTP53MAPTKDM4EUSP2 | |
| SCHEMBL3713385 | 0.81 | PLA2G10 (0.38) | TP53MAPTKDM4EUSP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |