Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708765 | 0.93 | FAAH (0.43) | PARP1BAZ2BBAZ2APRKCIDYRK1A | |
| SCHEMBL3698515 | 0.90 | PARP1 (0.44) | PARP1BAZ2BBAZ2APRKCIDYRK1A | |
| SCHEMBL3714031 | 0.82 | AR (0.48) | BAZ2BBAZ2ASHMT1RETHDAC8 | |
| SCHEMBL6432991 | 0.80 | NR1H4 (0.45) | AKR1C3AKR1C2 | |
| SCHEMBL3135455 | 0.76 | PARP1 (0.53) | PARP1BAZ2BBAZ2APRKCIDYRK1A | |
| SCHEMBL3701695 | 0.75 | PARP1 (0.51) | PARP1BAZ2BBAZ2APRKCIDYRK1A | |
| Hydrochloric Acid SCHEMBL29287827 | 0.75 | PARP1 (0.51) | PARP1BAZ2BBAZ2APRKCIDYRK1A | |
| Hydrochloric Acid SCHEMBL29287792 | 0.75 | PARP1 (0.51) | PARP1BAZ2BBAZ2APRKCIDYRK1A | |
| SCHEMBL27789898 | 0.74 | KDR (0.49) | — | |
| SCHEMBL18893559 | 0.73 | MEN1 (0.54) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197835-A1 | BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS | Prosidion Limited (GB) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009030962-A1 | BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS | PROSIDION LIMITED (GB) | 2009-03-12 | — | — | WO | disclosed |