Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711667 | 0.83 | YTHDC1 (0.36) | CYP3A4TP53 | |
| SCHEMBL3711291 | 0.80 | ALDH1A1 (0.35) | ALDH1A1KDM4ECYP3A4CYP1A2CLK4 | |
| SCHEMBL8613 | 0.78 | TP53 (0.43) | ALDH1A1KDM4ECYP3A4CYP1A2CYP2C19 | |
| SCHEMBL3705670 | 0.77 | PIK3CD (0.43) | ALDH1A1SMN1; SMN2KDM4ECYP3A4CYP1A2 | |
| SCHEMBL3716002 | 0.75 | TP53 (0.37) | ALDH1A1SMN1; SMN2CYP3A4HTTTP53 | |
| SCHEMBL865348 | 0.75 | KDM4E (0.45) | ALDH1A1SMN1; SMN2KDM4ECYP3A4CYP1A2 | |
| SCHEMBL15184799 | 0.71 | KDM4E (0.45) | ALDH1A1SMN1; SMN2KDM4ECYP3A4CYP1A2 | |
| SCHEMBL15184800 | 0.71 | KDM4E (0.45) | ALDH1A1SMN1; SMN2KDM4ECYP3A4CYP1A2 | |
| SCHEMBL3712961 | 0.67 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KDM4ECYP3A4CYP1A2 | |
| SCHEMBL716342 | 0.64 | KDR (0.36) | ALDH1A1KDM4ECYP3A4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396315-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092340-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-08-19 | — | — | WO | disclosed |