SCHEMBL8613

SCHEMBL8613

CCN(C(=O)O)c1cc2cccc(Cl)c2nc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.43
MAPK14 Q16539 2/20 0.36
CYP3A4 P08684 2/20 0.36
ALDH1A1 P00352 5/20 0.35
NPSR1 Q6W5P4 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KDM4E B2RXH2 2/20 0.35
MAPT P10636 2/20 0.35
HTT P42858 1/20 0.35
TRPM8 Q7Z2W7 2/20 0.34
KDR P35968 1/20 0.34
GLA P06280 1/20 0.34
TSHR P16473 1/20 0.34
GAA P10253 1/20 0.34
TSPO P30536 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3716002 0.86 TP53 (0.37) TP53MAPK14CYP3A4ALDH1A1MAPT
SCHEMBL3711667 0.85 YTHDC1 (0.36) TP53MAPK14CYP3A4TRPM8GAA
SCHEMBL716342 0.82 KDR (0.36) CYP3A4ALDH1A1NPSR1CYP1A2CYP2D6
SCHEMBL3705669 0.78 ALDH1A1 (0.43) TP53CYP3A4ALDH1A1CYP1A2CYP2D6
SCHEMBL3455164 0.73 TP53 (0.47) TP53CYP3A4ALDH1A1TRPM8GLA
SCHEMBL11064072 0.73 TP53 (0.54) TP53CYP3A4ALDH1A1HTTTRPM8
SCHEMBL845050 0.72 MAPT (0.37) TP53MAPK14CYP3A4ALDH1A1KDM4E
SCHEMBL1728322 0.72 ALDH1A1 (0.35) TP53MAPK14CYP3A4ALDH1A1NPSR1
SCHEMBL14047560 0.71 DRD4 (0.44) CYP3A4ALDH1A1NPSR1CYP1A2CYP2D6
SCHEMBL26617907 0.70 KEAP1 (0.47) TP53ALDH1A1KDM4EMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2499126-A1 FUSED BICYCLIC PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS UCB Pharma, S.A. (BE) 2012-09-19 EP disclosed
EP-2432784-A1 FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS UCB Pharma, S.A. (BE) 2012-03-28 EP disclosed
WO-2011058113-A1 FUSED BICYCLIC PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2011-05-19 WO disclosed
WO-2010133836-A1 FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2010-11-25 WO disclosed