Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | GHSR | Q92847 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613 | 0.86 | TP53 (0.43) | TP53TRPM8CYP3A4MAPTMAPK14 | |
| SCHEMBL3711667 | 0.81 | YTHDC1 (0.36) | TP53TRPM8CYP3A4MAPK14GAA | |
| SCHEMBL3705669 | 0.75 | ALDH1A1 (0.43) | TP53CYP3A4SMN1; SMN2LMNAKMT2A | |
| SCHEMBL3716004 | 0.74 | GHSR (0.38) | TP53TRPM8GHSRCYP3A4TDP1 | |
| SCHEMBL863898 | 0.74 | USP9X (0.36) | TP53TRPM8GHSRFABP4FABP5 | |
| SCHEMBL716342 | 0.70 | KDR (0.36) | TRPM8CYP3A4MAPTKMT2AALDH1A1 | |
| SCHEMBL3455164 | 0.70 | TP53 (0.47) | TP53TRPM8CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL11064072 | 0.70 | TP53 (0.54) | TP53TRPM8CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL14047560 | 0.66 | DRD4 (0.44) | CYP3A4LMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL3807502 | 0.65 | SIGMAR1 (0.62) | TDP1SMN1; SMN2LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396315-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092340-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-08-19 | — | — | WO | disclosed |