SCHEMBL3705671

SCHEMBL3705671

CC(C)c1cc(Oc2c(Cl)cc(N(CC(=O)O)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2Cl)ccc1O

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 13/20 0.55
THRA P10827 12/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3715134 0.93 THRB (0.55) THRBTHRA
SCHEMBL3707602 0.90 RORC (0.50) THRBTHRA
SCHEMBL3708498 0.87 THRA (0.61) THRBTHRA
SCHEMBL3702938 0.86 THRA (0.60) THRBTHRA
SCHEMBL3711950 0.85 THRA (0.59) THRBTHRA
SCHEMBL3708921 0.83 THRA (0.56) THRBTHRA
SCHEMBL3709214 0.82 RORC (0.50) THRBTHRA
SCHEMBL3707201 0.82 THRB (0.55) THRBTHRA
SCHEMBL3713885 0.80 THRA (0.57) THRBTHRA
SCHEMBL3710472 0.80 RORC (0.47) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010086878-A2 THYROID RECEPTOR MODULATORS CADILA HEALTHCARE LIMITED (IN) 2010-08-05 WO claimed
WO-2010086878-A2 THYROID RECEPTOR MODULATORS CADILA HEALTHCARE LIMITED (IN) 2010-08-05 WO disclosed