Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1785351 | 0.88 | CAPN1 (0.42) | GHSRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1784466 | 0.88 | GHSR (0.42) | GHSRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3702097 | 0.86 | PTGDR (0.39) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3704400 | 0.83 | ALDH1A1 (0.46) | GHSRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3709384 | 0.82 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL1790817 | 0.80 | ACLY (0.45) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL16464259 | 0.77 | MYC (0.46) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL1786846 | 0.77 | HCAR1 (0.47) | GHSRALDH1A1KDM4ELMNAHCRTR1 | |
| SCHEMBL1784772 | 0.77 | HSP90AA1 (0.37) | GHSRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1785903 | 0.76 | MAPT (0.41) | GHSRALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607357-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2205576-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009047558-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |