Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713072 | 0.80 | NOX1 (0.54) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23728219 | 0.80 | NOX1 (0.49) | MAPTALDH1A1TSHRKDM4EMEN1 | |
| SCHEMBL23728221 | 0.80 | NOX1 (0.49) | MAPTALDH1A1TSHRKDM4EMEN1 | |
| SCHEMBL3706136 | 0.78 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL30720835 | 0.77 | CYP1B1 (0.42) | GRK2MAPTTHRBSAE1UBA2 | |
| SCHEMBL23384891 | 0.75 | CYP1B1 (0.41) | GRK2MAPTTHRBSAE1UBA2 | |
| SCHEMBL3709908 | 0.74 | GAA (0.45) | ALDH1A1TSHRNLRP3KDM4EMEN1 | |
| SCHEMBL8590788 | 0.74 | MAOA (0.49) | MAPTSMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL24938717 | 0.73 | MAPT (0.42) | GRK2MAPTTHRBCYP1B1ALDH1A1 | |
| SCHEMBL11260465 | 0.71 | MAPT (0.57) | MAPTSAE1UBA2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102365020-B | Pyridazinone compounds | TAKEDA PHARMACEUTICAL | 2014-07-30 | — | — | CN | disclosed |
| EP-2393360-A1 | PYRIDAZINONE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090737-A1 | PYRIDAZINONE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-12 | — | — | WO | disclosed |