Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707004 | 0.74 | GRK2 (0.41) | GAATSHRALDH1A1KDM4ENLRP3 | |
| SCHEMBL23728221 | 0.74 | NOX1 (0.49) | GAATSHRALDH1A1KDM4EMEN1 | |
| SCHEMBL23728219 | 0.74 | NOX1 (0.49) | GAATSHRALDH1A1KDM4EMEN1 | |
| SCHEMBL518606 | 0.72 | CRHR1 (0.59) | GAACRHR1TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL11862777 | 0.70 | NFE2L2 (0.49) | GAATSHRL3MBTL1ALDH1A1 | |
| SCHEMBL11862765 | 0.70 | NFE2L2 (0.49) | GAATSHRL3MBTL1ALDH1A1 | |
| SCHEMBL1084996 | 0.69 | L3MBTL1 (0.63) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL29769835 | 0.69 | L3MBTL1 (0.63) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7648356 | 0.66 | GAA (0.61) | GAACRHR1TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL3713072 | 0.66 | NOX1 (0.54) | TSHRL3MBTL1ALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102365020-B | Pyridazinone compounds | TAKEDA PHARMACEUTICAL | 2014-07-30 | — | — | CN | disclosed |
| EP-2393360-A1 | PYRIDAZINONE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090737-A1 | PYRIDAZINONE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-12 | — | — | WO | disclosed |