Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 9/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.32 |
| ▸ | ACR | P10323 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705512 | 0.94 | LPAR1 (0.39) | LPAR1LPAR2LPAR3CYP11B1CYP11B2 | |
| SCHEMBL2338262 | 0.90 | LPAR1 (0.50) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL2335497 | 0.90 | LPAR1 (0.45) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3712570 | 0.88 | CYP2C9 (0.36) | LPAR1LPAR2LPAR3NR1H4 | |
| SCHEMBL3704161 | 0.87 | LPAR1 (0.47) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3714488 | 0.87 | L3MBTL1 (0.34) | LPAR1LPAR2LPAR3CYP11B1CYP11B2 | |
| SCHEMBL1246951 | 0.87 | CYP11B1 (0.40) | LPAR1LPAR2LPAR3CYP11B1CYP11B2 | |
| SCHEMBL3714465 | 0.86 | LPAR1 (0.45) | LPAR1LPAR2LPAR3PPARDFFAR1 | |
| SCHEMBL3702333 | 0.86 | LPAR1 (0.44) | LPAR1LPAR2LPAR3PPARDFFAR1 | |
| SCHEMBL3700609 | 0.85 | LPAR1 (0.46) | LPAR1LPAR2LPAR3PPARDNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |