Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245358 | 0.90 | NR1H4 (0.42) | LPAR1LPAR2LPAR3GPBAR1NR1H4 | |
| SCHEMBL1246307 | 0.90 | NR1H4 (0.44) | GPBAR1NR1H4MAPTTDP1SCN9A | |
| SCHEMBL1246467 | 0.87 | NR1H4 (0.43) | LPAR1LPAR2LPAR3GPBAR1NR1H4 | |
| SCHEMBL1245176 | 0.87 | NR1H4 (0.40) | LPAR1LPAR2LPAR3GPBAR1NR1H4 | |
| SCHEMBL3707597 | 0.87 | LPAR1 (0.46) | CYP11B1CYP11B2LPAR1LPAR2LPAR3 | |
| SCHEMBL1246476 | 0.86 | NR1H4 (0.42) | LPAR1LPAR2LPAR3GPBAR1NR1H4 | |
| SCHEMBL1246477 | 0.85 | NR1H4 (0.42) | GPBAR1NR1H4MAPTALDH1A1 | |
| SCHEMBL1246346 | 0.85 | SCN9A (0.38) | GPBAR1NR1H4MAPTALDH1A1SCN9A | |
| SCHEMBL1247748 | 0.85 | SCN9A (0.39) | GPBAR1NR1H4MAPTALDH1A1POLB | |
| SCHEMBL1245136 | 0.84 | NR1H4 (0.38) | NR1H4MAPTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |