Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 14/20 | 0.40 |
| ▸ | THRB | P10828 | 14/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706492 | 0.89 | THRB (0.40) | THRATHRBKMT2A | |
| SCHEMBL3703589 | 0.82 | THRB (0.44) | THRATHRB | |
| SCHEMBL3707850 | 0.81 | TSHR (0.44) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL3713193 | 0.80 | THRA (0.51) | THRATHRB | |
| SCHEMBL3708498 | 0.80 | THRA (0.61) | THRATHRB | |
| SCHEMBL3778662 | 0.80 | THRB (0.63) | THRATHRB | |
| SCHEMBL3705942 | 0.78 | THRB (0.45) | THRATHRBKMT2A | |
| SCHEMBL3807063 | 0.76 | THRB (0.58) | THRATHRB | |
| SCHEMBL3223034 | 0.75 | THRB (0.42) | THRATHRB | |
| SCHEMBL3713941 | 0.74 | THRB (0.50) | THRATHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |