Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 14/20 | 0.40 |
| ▸ | THRA | P10827 | 13/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707632 | 0.89 | THRA (0.40) | THRBTHRAKMT2A | |
| SCHEMBL3708122 | 0.84 | THRB (0.45) | THRBTHRA | |
| SCHEMBL3704624 | 0.82 | THRB (0.48) | THRBTHRA | |
| SCHEMBL3704685 | 0.82 | ESRRA (0.44) | THRBTHRA | |
| SCHEMBL3707649 | 0.81 | THRB (0.42) | THRBTHRA | |
| SCHEMBL3711114 | 0.81 | TSHR (0.44) | MEN1KMT2A | |
| SCHEMBL3712191 | 0.80 | THRA (0.51) | THRBTHRA | |
| SCHEMBL3708160 | 0.80 | THRA (0.61) | THRBTHRA | |
| SCHEMBL3702629 | 0.79 | THRB (0.42) | THRBTHRAKMT2A | |
| SCHEMBL3708478 | 0.79 | THRB (0.42) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |