Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2894380 | 1.00 | ELANE (1.00) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL14899925 | 0.93 | ELANE (0.89) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL13872092 | 0.93 | ELANE (0.87) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL13872095 | 0.93 | ELANE (0.87) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL2894512 | 0.92 | ELANE (0.86) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL1764353 | 0.92 | ELANE (1.00) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL3482731 | 0.92 | ELANE (1.00) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL392232 | 0.92 | ELANE (1.00) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL13872877 | 0.92 | ELANE (0.86) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL2896569 | 0.91 | ELANE (0.83) | ELANECYP2C9CYP3A4ADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101615-B2 | Chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, heart failure | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-24 | — | — | US | disclosed |
| US-8101615-B2 | Chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, heart failure | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-24 | — | — | US | disclosed |
| US-20100010024-A1 | USE OF1,4-DIARYL-DIHYDROPYRIMIDINE-2-ON DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTENSION | BAYER HEALTHCARE AG (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20100010024-A1 | USE OF1,4-DIARYL-DIHYDROPYRIMIDINE-2-ON DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTENSION | BAYER HEALTHCARE AG (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20100003709-A1 | Crystal Structure of Enzyme and Uses Thereof | BAYER HEALTHCARE AG (DE) | 2010-01-07 | — | — | US | disclosed |
| US-20100003709-A1 | Crystal Structure of Enzyme and Uses Thereof | BAYER HEALTHCARE AG (DE) | 2010-01-07 | — | — | US | disclosed |
| US-20080064704-A1 | 1,4-Diaryl-Dihydropyrimidin-2-Ones and Their Use as Human Neutrophil Elastase Inhibitors | BAYER HEALTHCARE AG (DE) | 2008-03-13 | — | — | US | disclosed |
| US-20080064704-A1 | 1,4-Diaryl-Dihydropyrimidin-2-Ones and Their Use as Human Neutrophil Elastase Inhibitors | BAYER HEALTHCARE AG (DE) | 2008-03-13 | — | — | US | disclosed |
| WO-2008003412-A1 | THE USE OF 1,4-DIARYL-DIHYDROPYRIMIDINE-2-ON DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTENSION | BAYER HEALTHCARE AG (DE) | 2008-01-10 | — | — | WO | disclosed |
| EP-1828233-A2 | CRYSTAL STRUCTURE OF ENZYME AND USES THEREOF | Bayer HealthCare AG (DE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006063792-A2 | CRYSTAL STRUCTURE OF ENZYME AND USES THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-22 | — | — | WO | disclosed |
| WO-2005082864-A1 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064704-A1 | 1,4-Diaryl-Dihydropyrimidin-2-Ones and Their Use as Human Neutrophil Elastase Inhibitors | SERPINB1, ELANE, MPO | ELANE 2/4885CYP2C9 2092/4885CYP3A4 1734/4885 |
| US-20100003709-A1 | Crystal Structure of Enzyme and Uses Thereof | SERPINB1, ELANE, MMP8 | ELANE 2/4885CYP2C9 1214/4885CYP3A4 830/4885 |
| US-20100010024-A1 | USE OF1,4-DIARYL-DIHYDROPYRIMIDINE-2-ON DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTENSION | PTGS1, DPYD, PTGIS | ELANE 2990/4885CYP2C9 1968/4885CYP3A4 2082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.