Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | ASIC3 | Q9UHC3 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24294087 | 0.87 | FEN1 (0.44) | MAPTFFAR4FFAR1ALDH1A1KDM4E | |
| SCHEMBL27682554 | 0.86 | APP (0.58) | MAPTFFAR4FFAR1ALDH1A1MEN1 | |
| SCHEMBL24554356 | 0.83 | GRM5 (0.53) | MAPTFFAR4FFAR1ALDH1A1KDM4E | |
| SCHEMBL719199 | 0.81 | APP (0.55) | MAPTFFAR4FFAR1APPASIC3 | |
| SCHEMBL16598714 | 0.79 | APP (0.52) | MAPTFFAR4FFAR1ALDH1A1KDM4E | |
| SCHEMBL24294400 | 0.79 | CYP11B1 (0.43) | MAPTFFAR4FFAR1ALDH1A1KDM4E | |
| SCHEMBL19188455 | 0.78 | FFAR1 (0.55) | MAPTFFAR4FFAR1ALDH1A1KDM4E | |
| SCHEMBL12478974 | 0.76 | MAPT (0.54) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL16598981 | 0.76 | MAPT (0.54) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL4438282 | 0.76 | MAPT (0.54) | MAPTFFAR1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107667107-B | Ethynyl derivatives | 豪夫迈·罗氏有限公司 | 2021-05-18 | — | — | CN | disclosed |
| EP-3331882-B1 | ETHYNYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| EP-3331882-B1 | ETHYNYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| US-10011607-B2 | Ethynyl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10011607-B2 | Ethynyl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10011607-B2 | Ethynyl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-07-03 | — | — | US | disclosed |
| EP-3331882-A1 | ETHYNYL DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2018-06-13 | — | — | EP | disclosed |
| US-20180127429-A1 | ETHYNYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127429-A1 | ETHYNYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127429-A1 | ETHYNYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-05-10 | — | — | US | disclosed |
| WO-2017021384-A1 | ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-09 | — | — | WO | disclosed |
| WO-2017021384-A1 | ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-09 | — | — | WO | disclosed |
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011607-B2 | Ethynyl derivatives | CCRL2, MC2R, CCR2 | MAPT 3788/4885FFAR4 1424/4885FFAR1 599/4885 |
| US-20180127429-A1 | ETHYNYL DERIVATIVES | CCRL2, MC2R, CCR2 | MAPT 3788/4885FFAR4 1424/4885FFAR1 599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.