Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708422 | 0.94 | KDM4E (0.40) | KDM4ETP53ROCK2LPAR1CA12 | |
| SCHEMBL2335475 | 0.87 | KDM4E (0.39) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL3702204 | 0.86 | TP53 (0.38) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL3715778 | 0.86 | KDM4E (0.38) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL3704734 | 0.85 | KDM4E (0.35) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL3704655 | 0.84 | L3MBTL1 (0.38) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL3703091 | 0.83 | KDM4E (0.36) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL2341939 | 0.82 | KDM4E (0.35) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL3705660 | 0.81 | SYK (0.35) | KDM4ESMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL1246372 | 0.81 | KDM4E (0.41) | KDM4ESMN1; SMN2NPC1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |