Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245270 | 0.87 | KDM4E (0.44) | KDM4ENPC1NR1H4PPARDALDH1A1 | |
| SCHEMBL3708422 | 0.87 | KDM4E (0.40) | KDM4ENR1H4PPARDPPARGNAMPT | |
| SCHEMBL1246914 | 0.85 | KDM4E (0.39) | KDM4ENPC1NR1H4PPARDPPARG | |
| SCHEMBL1247569 | 0.81 | SCN9A (0.39) | KDM4ENPC1NR1H4PPARDSCN9A | |
| SCHEMBL3708181 | 0.81 | KDM4E (0.38) | KDM4ENPC1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1247556 | 0.79 | KDM4E (0.40) | KDM4ENPC1PPARDPPARGSCN9A | |
| SCHEMBL1247276 | 0.79 | KDM4E (0.37) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL1246323 | 0.78 | PPARD (0.39) | KDM4ENR1H4PPARDALDH1A1LMNA | |
| SCHEMBL1247291 | 0.78 | SCN9A (0.41) | KDM4ENPC1NR1H4PPARDLMNA | |
| SCHEMBL9902690 | 0.77 | L3MBTL1 (0.42) | KDM4ENPC1ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |