Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473095 | 0.78 | MAOA (0.59) | AKT2MAOBMAOAPNMTTAAR1 | |
| SCHEMBL3708719 | 0.78 | MAPT (0.39) | MAPTCYP2C9CYP2C19MAOBMAOA | |
| Hydrochloric Acid SCHEMBL21879608 | 0.77 | MAOB (0.57) | AKT2MAOBMAOAPNMTTAAR1 | |
| SCHEMBL5218251 | 0.76 | PNMT (0.50) | AKT2MAOBMAOAPNMTTAAR1 | |
| SCHEMBL9667972 | 0.76 | SLC6A4 (0.50) | AKT2MAOBMAOAPNMTTAAR1 | |
| SCHEMBL12585406 | 0.75 | AKT2 (0.49) | MAPTCYP2C9CYP2C19AKT2MAOB | |
| Formic Acid SCHEMBL6207884 | 0.74 | MAOA (0.49) | AKT2MAOBMAOAPNMTTAAR1 | |
| SCHEMBL6430626 | 0.71 | AKT2 (0.46) | MAPTAKT2MAOBMAOAPNMT | |
| SCHEMBL208131 | 0.67 | AOC3 (0.43) | AKT2MAOBMAOAPNMTTAAR1 | |
| SCHEMBL2470610 | 0.66 | SSTR1 (0.49) | PNMTKMT2ATAAR1CYP3A4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |