Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708683 | 0.78 | MAPT (0.43) | MAPTCYP2C9CYP2C19MAOBMAOA | |
| SCHEMBL3711425 | 0.63 | — | — | |
| SCHEMBL13879702 | 0.63 | MEN1 (0.36) | MAPTKMT2AALDH1A1 | |
| SCHEMBL3026505 | 0.62 | ALDH1A1 (0.52) | RECQLMAOBMAOAALDH1A1TDP1 | |
| SCHEMBL206056 | 0.62 | TAAR1 (0.44) | MAPTCYP2C9CYP2C19HSD11B1ALDH1A1 | |
| SCHEMBL25209309 | 0.61 | PNMT (0.48) | HSD11B1 | |
| SCHEMBL30174702 | 0.61 | PNMT (0.48) | HSD11B1 | |
| SCHEMBL2473095 | 0.61 | MAOA (0.59) | MAOBMAOAHSD11B1 | |
| SCHEMBL3028296 | 0.61 | OPRM1 (0.38) | MAPTCYP2C9KMT2AALDH1A1TDP1 | |
| SCHEMBL4428866 | 0.61 | KMT2A (0.40) | MAPTCYP2C9CYP2C19MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |