Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PPID | Q08752 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PPIB | P23284 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584747 | 0.86 | GAA (0.68) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL3715221 | 0.82 | RECQL (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL14498356 | 0.81 | GAA (0.53) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL66328 | 0.80 | GAA (0.64) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL12401348 | 0.79 | GAA (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL13602806 | 0.79 | GAA (0.63) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL27825811 | 0.78 | GAA (0.61) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL7294998 | 0.77 | GAA (0.54) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL20802464 | 0.76 | MEN1 (0.46) | GAAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5205018 | 0.76 | GAA (0.64) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |