Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | MGAM | O43451 | 1/20 | 0.64 |
| ▸ | SI | P14410 | 1/20 | 0.64 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584747 | 0.84 | GAA (0.68) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL18174485 | 0.84 | GAA (0.42) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL14898408 | 0.82 | GAA (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL4586391 | 0.82 | GAA (0.55) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL4578705 | 0.80 | GAA (0.56) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL3220536 | 0.80 | GAA (0.56) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL4578702 | 0.80 | GAA (0.56) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL14258687 | 0.80 | GAA (0.56) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL12072447 | 0.80 | MGAM (0.48) | GAAMGAMSIMGAM2TSHR | |
| Malonic Acid Diethyl Ester SCHEMBL1331824 | 0.79 | GAA (1.00) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133203-A1 | Substituted Pyrazolo-Pyrimidines and Uses Thereof | Verge Analytics, Inc. (US) | 2023-05-04 | — | — | US | disclosed |
| CN-108342422-B | Preparation method of N-substituted amino carbonyl ester compound and application of immobilized lipase | 北京海美桐医药科技有限公司 | 2020-08-14 | — | — | CN | disclosed |
| WO-2019057821-A1 | COUMARIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF FOR THE TREATMENT OF CANCER | LEAD DISCOVERY CENTER GMBH (DE) | 2019-03-28 | — | — | WO | disclosed |
| US-8501784-B2 | 2-pyridone derivatives as neutrophil elastase inhibitors and their use | ASTRAZENECA AB (SE) | 2013-08-06 | — | — | US | disclosed |
| US-20120035157-A1 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | US | disclosed |
| US-8063073-B2 | 2-pyridone derivatives as neutrophil elastase inhibitors and their use | ASTRAZENECA AB (SE) | 2011-11-22 | — | — | US | disclosed |
| US-20070203129-A1 | 2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | US | disclosed |
| EP-1554246-B1 | DIHYDROPYRIDINONE DERIVATIVES AS HNE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2007-08-22 | — | — | EP | disclosed |
| US-7230017-B2 | Dihydropyridinone derivatives | BAYER HEALTHCARE AG (DE) | 2007-06-12 | — | — | US | disclosed |
| US-20070043036-A1 | 2-Pyridone derivatives as neutrophil elastase inhibitors and their use | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | US | disclosed |
| US-20060100207-A1 | Dihydropyridinone derivatives | BAYER HEALTHCARE AG (DE) | 2006-05-11 | — | — | US | disclosed |
| US-4407797-A | ANTIULCER AGENT | RHONE-POULENC SANTE (FR) | 1983-10-04 | — | — | US | disclosed |
| US-4073783-A | PENICILLINS | PFIZER INC. (US) | 1978-02-14 | — | — | US | disclosed |
| US-4025506-A | PENICILLINS | PFIZER INC. (US) | 1977-05-24 | — | — | US | disclosed |
| US-4025504-A | PENICILLINS | PFIZER INC. (US) | 1977-05-24 | — | — | US | disclosed |
| US-3951952-A | 6-(ALPHA-(AMIDINO-AND IMIDOYLAMINOALKANOYLAMINO)ARACYLAMINO)-PENICILLANIC ACIDS | PFIZER INC. (US) | 1976-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100207-A1 | Dihydropyridinone derivatives | TNNI3, DHPS, TNNT2 | GAA 2947/4885MGAM 3719/4885SI 4374/4885 |
| US-20120035157-A1 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE | SERPINB1, ELANE, SERPINE1 | GAA 1032/4885MGAM 2461/4885SI 2772/4885 |
| US-20070203129-A1 | 2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use | SERPINB1, ELANE, SERPINE1 | GAA 1057/4885MGAM 2259/4885SI 2643/4885 |
| US-20230133203-A1 | Substituted Pyrazolo-Pyrimidines and Uses Thereof | PIKFYVE, PIP4K2B, PIP4K2C | GAA 792/4885MGAM 3989/4885SI 4381/4885 |
| US-20070043036-A1 | 2-Pyridone derivatives as neutrophil elastase inhibitors and their use | SERPINB1, ELANE, SERPINE1 | GAA 1057/4885MGAM 2259/4885SI 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.