Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12481728 | 0.89 | HTR2C (0.57) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| SCHEMBL7370885 | 0.81 | HTR2C (0.62) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| SCHEMBL1912703 | 0.80 | HTR2C (0.51) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| SCHEMBL12481459 | 0.80 | HTR2C (0.48) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| SCHEMBL3413391 | 0.78 | HTR2C (0.62) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL4269341 | 0.77 | ADRA1D (0.54) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| SCHEMBL350335 | 0.77 | HSD11B1 (0.65) | HTR2CHTR2BALDH1A1HSD11B1 | |
| SCHEMBL3552550 | 0.75 | HTR2C (0.72) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| SCHEMBL8002464 | 0.74 | ADRA1A (0.66) | HTR2CHTR2BADRA1DADRA1AADRA1B | |
| SCHEMBL1115308 | 0.74 | HTR2C (0.70) | HTR2CHTR2BADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |