Known targets — ChEMBL curated mechanism
TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8
The experimentally established mechanism targets of Vincristine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A known ✓ | P04350 | 6/20 | 0.97 |
| ▸ | TUBB known ✓ | P07437 | 6/20 | 0.97 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 6/20 | 0.97 |
| ▸ | TUBA1B known ✓ | P68363 | 6/20 | 0.97 |
| ▸ | TUBA4A known ✓ | P68366 | 6/20 | 0.97 |
| ▸ | TUBB4B known ✓ | P68371 | 6/20 | 0.97 |
| ▸ | TUBB3 known ✓ | Q13509 | 6/20 | 0.97 |
| ▸ | TUBB2A known ✓ | Q13885 | 6/20 | 0.97 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 6/20 | 0.97 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 6/20 | 0.97 |
| ▸ | TUBA1A known ✓ | Q71U36 | 6/20 | 0.97 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 6/20 | 0.97 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 6/20 | 0.97 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 6/20 | 0.97 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 6/20 | 0.97 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vincristine SCHEMBL3998 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL4640472 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL4709855 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL2946485 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL18398051 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL29519343 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL29895946 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL4742962 | 0.99 | MAPT (0.98) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL18402663 | 0.98 | LMNA (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL4769981 | 0.98 | LMNA (1.00) | MAPTMEN1KMT2ALMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 242246 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144783-A1 | COMPOSITION FOR PREVENTING OR TREATING PERIPHERAL NEUROPATHY, CONTAINING ISOQUINOLINE DERIVATIVE AS ACTIVE INGREDIENT | ALTMEDICAL CO., LTD. (KR) | 2026-05-28 | — | — | US | claimed |
| US-20260144890-A1 | ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR CONJUGATED TO AN ANTIBODY | MyricX Pharma Limited (GB) | 2026-05-28 | — | — | US | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| EP-4748859-A2 | CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF | The Regents of the University of California (US) | 2026-05-27 | — | — | EP | claimed |
| EP-3727367-B1 | VITAMIN K2 COMPOSITIONS FOR USE IN THE TREATMENT OF DRUG INDUCED NEUROPATHY | SYNERGIA LIFE SCIENCES PVT LTD (IN) | 2026-05-27 | — | — | EP | claimed |
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122075497-A | Use of NLRP3 agonist for tumor treatment | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075669-A | Composition and application thereof in preparation of drugs for preventing and treating lymphoma | — | 2026-05-26 | — | — | CN | claimed |
| CN-117624275-B | Liver-targeting sugar ligand molecule modified by double-antenna GalNAc and drug carrying system thereof | JIAYING UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-116209439-B | Cereblon protein modulators | Saint Jude Children's Research Hospital Ltd. (US) | 2026-05-26 | — | — | CN | claimed |
| EP-0019423-A1 | Pharmaceutical and dietary composition comprising gamma-linolenic acids | EFAMOL LIMITED (GB) | 1980-11-26 | — | — | EP | claimed |
| EP-0018231-A2 | A process for the preparation of bis-indole-alkaloids and acid addition salts thereof and new bis-indole-alkaloids, pharmaceutical compositions containing them and their use as antitumour agents | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1980-10-29 | — | — | EP | claimed |
| US-4208414-A | Vinblastine in rheumatoid arthritis | ELI LILLY AND COMPANY (US) | 1980-06-17 | — | — | US | claimed |
| US-4199505-A | FROM VINCRISTINE OR VINBLASTINE; SELECTIVE EPOXIDATION | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1980-04-22 | — | — | US | claimed |
| EP-0007206-A1 | Phenethanolamines, their formulations, preparation and use | ELI LILLY AND COMPANY (US) | 1980-01-23 | — | — | EP | claimed |
| US-4172077-A | Process for the isolation of alkaloid components from the plant Vinca Rosea L. | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1979-10-23 | — | — | US | claimed |
| EP-0004770-A2 | Pharmaceutical and dietary composition comprising gamma-linolenic acids | EFAMOL LIMITED (GB) | 1979-10-17 | — | — | EP | claimed |
| US-4106488-A | Cancer treatment method | GORDON, DAVID, SKOKIE, ILLINOIS | 1978-08-15 | — | — | US | claimed |
| US-4029663-A | ALKALOIDS, MITOTIC INHIBITORS | ELI LILLY AND COMPANY (US) | 1977-06-14 | — | — | US | claimed |
| US-3932417-A | Dimeric indole alkaloid purification process | ELI LILLY AND COMPANY (US) | 1976-01-13 | — | — | US | claimed |