Vincristine

Vincristine

SCHEMBL3998

CC[C@]1(O)C[C@H]2C[N@](CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8

The experimentally established mechanism targets of Vincristine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A known ✓ P04350 6/20 0.97
TUBB known ✓ P07437 6/20 0.97
TUBA3C known ✓ P0DPH7 6/20 0.97
TUBA1B known ✓ P68363 6/20 0.97
TUBA4A known ✓ P68366 6/20 0.97
TUBB4B known ✓ P68371 6/20 0.97
TUBB3 known ✓ Q13509 6/20 0.97
TUBB2A known ✓ Q13885 6/20 0.97
TUBB8 known ✓ Q3ZCM7 6/20 0.97
TUBA3E known ✓ Q6PEY2 6/20 0.97
TUBA1A known ✓ Q71U36 6/20 0.97
TUBA1C known ✓ Q9BQE3 6/20 0.97
TUBB6 known ✓ Q9BUF5 6/20 0.97
TUBB2B known ✓ Q9BVA1 6/20 0.97
TUBB1 known ✓ Q9H4B7 6/20 0.97
MAPT P10636 8/20 1.00
MEN1 O00255 7/20 1.00
KMT2A Q03164 7/20 1.00
LMNA P02545 6/20 1.00
HIF1A Q16665 5/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Vincristine SCHEMBL4640472 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL4709855 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL2946485 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL18398051 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL3710 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL29519343 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL29895946 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL4742962 0.99 MAPT (0.98) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL18402663 0.98 LMNA (1.00) MAPTMEN1KMT2ALMNAHIF1A
Vincristine SCHEMBL4769981 0.98 LMNA (1.00) MAPTMEN1KMT2ALMNAHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 46750 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132141-A1 PROTEIN PHOSPHATASE 2A ACTIVATORS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-14 US claimed
US-20260125428-A1 SYNTHETIC TRIPLEX PEPTIDE NUCLEIC ACID-BASED INHIBITORS FOR CANCER THERAPY UNIV CONNECTICUT (US) 2026-05-07 US claimed
EP-4735116-A2 ANTI-TRAILR2 ANTIGEN-BINDING PROTEINS AND USES THEREOF ODYSSEY THERAPEUTICS, INC. (US) 2026-05-06 EP claimed
EP-3856736-B1 NOVEL COMPOUNDS AS NADPH OXIDASE INHIBITORS CALLIDITAS THERAPEUTICS SUISSE SA (CH) 2026-05-06 EP claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260109699-A1 AZOLE DERIVATIVES AS SHP2 INHIBITORS IRBM S.P.A. (IT) 2026-04-23 US claimed
EP-4727959-A1 BIOMARKERS AND METHODS OF TREATMENT OF FOLLICULAR LYMPHOMA Bristol-Myers Squibb Company (US) 2026-04-22 EP claimed
US-20260102373-A1 LYMPH DIRECTING PRODRUGS MONASH UNIVERSITY (AU) 2026-04-16 US claimed
EP-4722240-A1 COMBINATION OF ANTIBODIES, OR ANTIGEN-BINDING FRAGMENTS THEREOF, FOR THE TREATMENT OF CANCERS AND COMPOSITIONS THEREOF Xenothera (FR) 2026-04-08 EP claimed
US-20260076872-A1 POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME SIO2 MEDICAL PRODUCTS LLC (US) 2026-03-19 US claimed
EP-0335966-A4 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS. MATRIX PHARMA INC (US) 1990-02-20 EP claimed
US-4883805-A LEUKEMIA TREATMENT TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 1989-11-28 US claimed
EP-0335966-A1 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS MATRIX PHARMACEUTICALS, INC. (US) 1989-10-11 EP claimed
WO-1989002734-A1 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS MATRIX PHARMACEUTICALS, INC. (US) 1989-04-06 WO claimed
EP-0298192-A1 Stable, injectable solutions of vincristine salts Teva Pharmaceutical Industries Limited (IL) 1989-01-11 EP claimed
US-4711782-A Prolonged release microcapsules and their production TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-12-08 US claimed
US-4619935-A Stable oncolytic formulations ELI LILLY AND COMPANY (US) 1986-10-28 US claimed
EP-0120907-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY Aston Molecules Limited (GB) 1984-10-10 EP claimed
WO-1984001506-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY UNIV BIRMINGHAM (GB) 1984-04-26 WO claimed
EP-0010964-A1 Ravidomycin, process of preparation and pharmaceutical compositions containing same AYERST, MCKENNA AND HARRISON INC. (CA) 1980-05-14 EP claimed