Known targets — ChEMBL curated mechanism
TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8
The experimentally established mechanism targets of Vincristine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A known ✓ | P04350 | 6/20 | 0.97 |
| ▸ | TUBB known ✓ | P07437 | 6/20 | 0.97 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 6/20 | 0.97 |
| ▸ | TUBA1B known ✓ | P68363 | 6/20 | 0.97 |
| ▸ | TUBA4A known ✓ | P68366 | 6/20 | 0.97 |
| ▸ | TUBB4B known ✓ | P68371 | 6/20 | 0.97 |
| ▸ | TUBB3 known ✓ | Q13509 | 6/20 | 0.97 |
| ▸ | TUBB2A known ✓ | Q13885 | 6/20 | 0.97 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 6/20 | 0.97 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 6/20 | 0.97 |
| ▸ | TUBA1A known ✓ | Q71U36 | 6/20 | 0.97 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 6/20 | 0.97 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 6/20 | 0.97 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 6/20 | 0.97 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 6/20 | 0.97 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vincristine SCHEMBL3710 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL2946485 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL18398051 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL3998 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL4640472 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL29519343 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL29895946 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL4742962 | 0.99 | MAPT (0.98) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL3709 | 0.98 | LMNA (1.00) | MAPTMEN1KMT2ALMNAHIF1A | |
| Vincristine SCHEMBL14177979 | 0.98 | LMNA (1.00) | MAPTMEN1KMT2ALMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426249-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | The Regents of The University of Michigan (US) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017184751-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERTENSION | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017165663-A1 | BIOMARKERS FOR CANCER ASSOCIATED WITH HEDGEHOG PATHWAY ACTIVITY AND RELATED USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-09-28 | — | — | WO | disclosed |
| WO-2017155991-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2016187544-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-24 | — | — | WO | disclosed |
| EP-2970965-A2 | DNAI FOR THE MODULATION OF GENES | Pronai Therapeutics, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144942-A2 | DNAI FOR THE MODULATION OF GENES | PRONAI THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-2057173-B1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| EP-2697374-A2 | MICRO-RNA INHIBITORS AND THEIR USES IN DISEASE | Beth Israel Deaconess Medical Center, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| WO-2013078392-A1 | METHODS AND COMPOSITIONS INVOLVING INDUCED SENESCENT CELLS FOR CANCER TREATMENT | THE UNIVERSITY OF CHICAGO (US) | 2013-05-30 | — | — | WO | disclosed |
| WO-2013052943-A2 | SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHGIAN (US) | 2013-04-11 | — | — | WO | disclosed |
| WO-2012142313-A2 | MICRO-RNA INHIBITORS AND THEIR USES IN DISEASE | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| EP-1915377-A1 | PYRAZOLO PYRIMIDINES USEFUL AS AURORA KINASE INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007013964-A1 | PYRAZOLO PYRIMIDINES USEFUL AS AURORA KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2007-02-01 | — | — | WO | disclosed |