Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188616 | 0.94 | DYRK1A (0.56) | DYRK1ACCR5MAPK1SMN1; SMN2JAK2 | |
| SCHEMBL3714261 | 0.91 | DYRK1A (0.54) | DYRK1AJAK2JAK3RAB9ANPC1 | |
| SCHEMBL3719071 | 0.86 | MAPK1 (0.49) | MAPK1SMN1; SMN2 | |
| SCHEMBL13188396 | 0.85 | DYRK1A (0.57) | DYRK1AMAPK1JAK2JAK3RAB9A | |
| SCHEMBL3714558 | 0.83 | JAK1 (0.49) | DYRK1AMAPK1SMN1; SMN2JAK2JAK3 | |
| SCHEMBL3711302 | 0.82 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3720383 | 0.81 | AURKA (0.46) | MAPK1SMN1; SMN2 | |
| SCHEMBL3717935 | 0.81 | MAPK1 (0.50) | MAPK1SMN1; SMN2 | |
| SCHEMBL3711313 | 0.80 | MAPK1 (0.49) | MAPK1SMN1; SMN2JAK2 | |
| SCHEMBL13187747 | 0.80 | SMN1; SMN2 (0.53) | MAPK1SMN1; SMN2RAB9ANPC1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |